TY - JOUR
T1 - The Somatic Mosaicism across Human Tissues Network
AU - The Somatic Mosaicism across Human Tissues Network
AU - Tool and Technology Development
AU - Data Analysis Center (UM1DA058230)
AU - Genome Characterization Center
AU - Tissue Procurement Center (U24MH133204)
AU - Organizational Center (U24NS132103)
AU - National Institutes of Health
AU - University of Massachusetts Chan Medical School – Thomas G. Fazzio (UG3NS132136)
AU - Case Western University – Fulai Jin (UG3NS132061)
AU - Broad Institute of MIT and Harvard – Fei Chen (UG3NS132135)
AU - Dana Farber Cancer Institute – Kathleen H. Burns (UG3NS132127)
AU - Boston’s Children Hospital – Christopher A. Walsh (UG3NS132138)
AU - New York University – Gilad D. Evrony (UG3NS132024)
AU - Weill Cornell Medicine – Dan A. Landau (UG3NS132139)
AU - University of Utah – Gabor T. Marth (UG3NS132134)
AU - Mayo Clinic – Alexej Abyzov (UG3NS132128)
AU - Baylor College of Medicine – Fritz J. Sedlazeck (UG3NS132105)
AU - Baylor College of Medicine – Chenghang Zong (UG3NS132132)
AU - Stanford University – Alexander E. Urban (UG3NS132146)
AU - Boston’s Children Hospital – Sangita Choudhury (UG3NS132144)
AU - University of Michigan – Ryan E. Mills (UG3NS132084)
AU - New York Genome Center – Soren Germer (UM1DA058236)
AU - Washington University – Ting Wang (UM1DA058219)
AU - Broad Institute of MIT and Harvard – Kristin G. Ardlie (UM1DA058235)
AU - Baylor College of Medicine – Richard A. Gibbs (UM1DA058229)
AU - University of Washington and Seattle Children’s Research Institute – James T. Bennett (UM1DA058220)
AU - Coorens, Tim H.H.
AU - Oh, Ji Won
AU - Choi, Yujin Angelina
AU - Lim, Nam Seop
AU - Zhao, Boxun
AU - Voshall, Adam
AU - Abyzov, Alexej
AU - Antonacci-Fulton, Lucinda
AU - Aparicio, Samuel
AU - Ardlie, Kristin G.
AU - Bell, Thomas J.
AU - Bennett, James T.
AU - Bernstein, Bradley E.
AU - Blanchard, Thomas G.
AU - Boyle, Alan P.
AU - Buenrostro, Jason D.
AU - Burns, Kathleen H.
AU - Chen, Fei
AU - Chen, Rui
AU - Choudhury, Sangita
AU - Doddapaneni, Harsha V.
AU - Eichler, Evan E.
AU - Evrony, Gilad D.
AU - Faith, Melissa A.
AU - Fazzio, Thomas G.
AU - Fulton, Robert S.
AU - Garber, Manuel
AU - Gehlenborg, Nils
AU - Germer, Soren
AU - Getz, Gad
AU - Gibbs, Richard A.
AU - Hernandez, Raquel G.
AU - Jin, Fulai
AU - Korbel, Jan O.
AU - Landau, Dan A.
AU - Lawson, Heather A.
AU - Lennon, Niall J.
AU - Li, Heng
AU - Li, Yan
AU - Loh, Po Ru
AU - Marth, Gabor
AU - McConnell, Michael J.
AU - Mills, Ryan E.
AU - Montgomery, Stephen B.
AU - Natarajan, Pradeep
AU - Park, Peter J.
AU - Satija, Rahul
AU - Sedlazeck, Fritz J.
AU - Shao, Diane D.
AU - Cheng, Alexandre Pellan
N1 - Publisher Copyright:
© Springer Nature Limited 2025.
PY - 2025/7/3
Y1 - 2025/7/3
N2 - From fertilization onwards, the cells of the human body acquire variations in their DNA sequence, known as somatic mutations. These postzygotic mutations arise from intrinsic errors in DNA replication and repair, as well as from exposure to mutagens. Somatic mutations have been implicated in some diseases, but a fundamental understanding of the frequency, type and patterns of mutations across healthy human tissues has been limited. This is primarily due to the small proportion of cells harbouring specific somatic variants within an individual, making them more challenging to detect than inherited variants. Here we describe the Somatic Mosaicism across Human Tissues Network, which aims to create a reference catalogue of somatic mutations and their clonal patterns across 19 different tissue sites from 150 non-diseased donors and develop new technologies and computational tools to detect somatic mutations and assess their phenotypic consequences, including clonal expansions. This strategy enables a comprehensive examination of the mutational landscape across the human body, and provides a comparison baseline for somatic mutation in diseases. This will lead to a deep understanding of somatic mutations and clonal expansions across the lifespan, as well as their roles in health, in ageing and, by comparison, in diseases.
AB - From fertilization onwards, the cells of the human body acquire variations in their DNA sequence, known as somatic mutations. These postzygotic mutations arise from intrinsic errors in DNA replication and repair, as well as from exposure to mutagens. Somatic mutations have been implicated in some diseases, but a fundamental understanding of the frequency, type and patterns of mutations across healthy human tissues has been limited. This is primarily due to the small proportion of cells harbouring specific somatic variants within an individual, making them more challenging to detect than inherited variants. Here we describe the Somatic Mosaicism across Human Tissues Network, which aims to create a reference catalogue of somatic mutations and their clonal patterns across 19 different tissue sites from 150 non-diseased donors and develop new technologies and computational tools to detect somatic mutations and assess their phenotypic consequences, including clonal expansions. This strategy enables a comprehensive examination of the mutational landscape across the human body, and provides a comparison baseline for somatic mutation in diseases. This will lead to a deep understanding of somatic mutations and clonal expansions across the lifespan, as well as their roles in health, in ageing and, by comparison, in diseases.
UR - https://www.scopus.com/pages/publications/105010500373
U2 - 10.1038/s41586-025-09096-7
DO - 10.1038/s41586-025-09096-7
M3 - Review Article
C2 - 40604182
AN - SCOPUS:105010500373
SN - 0028-0836
VL - 643
SP - 47
EP - 59
JO - Nature
JF - Nature
IS - 8070
ER -